Article
The Receptor Binding Domain of SARS-CoV-2 Lambda Variant Has a Better Chance Than the Delta Variant in Evading BNT162b2 COVID-19 mRNA Vaccine-Induced Humoral Immunity.
International journal of molecular sciences - 26 Sept 2022
Liu Haolin, Wei Pengcheng, Aviszus Katja, Zhang Qianqian, Linderberger Jared, Yang John, Liu Junfeng, Chen Zhongzhou, Waheed Hassan, Reynoso Lyndon, Downey Gregory P, Frankel Stephen K, Kappler John W, Marrack Philippa, Zhang Gongyi
Abstract excerpt
The SARS-CoV-2 Delta and Lambda variants had been named variants of concern (VOC) and variants of interest (VOI), respectively, by the World Health Organization (WHO). Both variants have two mutations in the spike receptor binding domain (RBD) region, with L452R and T478K mutations in the Delta variant, and L452Q and F490S mutations in the Lambda variant. We used surface plasmon resonance (SPR)-based technology...
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