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LRRC15 inhibits SARS-CoV-2 cellular entry in trans

13 Oct 2022

Abstract excerpt

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is mediated by the entry receptor angiotensin-converting enzyme 2 (ACE2). Although attachment factors and coreceptors facilitating entry are extensively studied, cellular entry factors inhibiting viral entry are largely unknown. Using a surfaceome CRISPR activation screen, we identified human LRRC15 as an inhibitory attachment factor for...

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PMID: 36228039
DOI: 10.1371/journal.pbio.3001805

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