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Article

Genetic variants determine intrafamilial variability of SARS-CoV-2 clinical outcomes in 19 Italian families.

PloS one - 1 Jan 2022

Azzarà Alessia, Cassano Ilaria, Paccagnella Elisa, Tirindelli Maria Cristina, Nobile Carolina, Schittone Valentina, Lintas Carla, Sacco Roberto, Gurrieri Fiorella

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of outcomes characterized by a high heterogeneity in both symptomatology and susceptibility to the disease. In such a perspective, COVID-19 may be considered as a multifactorial disease featured by the interaction between the environment, which is the virus itself, and the genetic profile of the host. Our analysis aimed...

Topics

COVID-19
Humans
Polymorphism, Single Nucleotide
SARS-CoV-2
Virus Diseases
Virus Internalization

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 36228008
DOI: 10.1371/journal.pone.0275988
PMCID: PMC9560599

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-36228008-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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