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Article

Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis.

mBio - 20 Dec 2022

Grace Cooper Alastair, Sousa Carvalho Kátia Silene, Sousa Lima Mayara Ingrid, Costa Silva Vladimir, Reis-Cunha João Luís, Brune Matthew J, Forrester Sarah, Pedrozo E Silva de Azevedo Conceição de Maria, Costa Dorcas Lamounier, Speed Doug, Mottram Jeremy C, Jeffares Daniel C, Costa Carlos H N

Abstract excerpt

Visceral leishmaniasis (VL) is a potentially fatal disease caused mainly by Leishmania infantum in South America and Leishmania donovani in Asia and Africa. Disease outcomes have been associated with patient genotype, nutrition, age, sex, comorbidities, and coinfections. In this study, we examine the effects of parasite genetic variation on VL disease severity in Brazil. We collected and sequenced the genomes of...

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Identifiers

PMID: 36222512
DOI: 10.1128/mbio.02068-22
PMCID: PMC9765272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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