Article
Label-free imaging of M1 and M2 macrophage phenotypes in the human dermis in vivo using two-photon excited FLIM.
eLife - 6 Oct 2022
Kröger Marius, Scheffel Jörg, Shirshin Evgeny A, Schleusener Johannes, Meinke Martina C, Lademann Jürgen, Maurer Marcus, Darvin Maxim E
Abstract excerpt
Macrophages (ΜΦs) are important immune effector cells that promote (M1 ΜΦs) or inhibit (M2 ΜΦs) inflammation and are involved in numerous physiological and pathogenic immune responses. Their precise role and relevance, however, are not fully understood for lack of noninvasive quantification methods. Here, we show that two-photon excited fluorescence lifetime imaging (TPE-FLIM), a label-free noninvasive method,...
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