Article
A three-dimensional atlas of human dermal leukocytes, lymphatics, and blood vessels.
The Journal of investigative dermatology - 1 Apr 2014
Wang Xiao-Nong, McGovern Naomi, Gunawan Merry, Richardson Connor, Windebank Martin, Siah Tee-Wei, Lim Hwee-Ying, Fink Katja, Yao Li Jackson L, Ng Lai G, Ginhoux Florent, Angeli Veronique, Collin Matthew, Haniffa Muzlifah
Abstract excerpt
Dendritic cells (DCs), macrophages (Mφ), and T cells are major components of the skin immune system, but their interstitial spatial organization is poorly characterized. Using four-channel whole-mount immunofluorescence staining of the human dermis, we demonstrated the three-dimensional distribution of CD31(+) blood capillaries, LYVE-1(+) lymphatics, discrete populations of CD11c(+) myeloid DCs, FXIIIa(+) Mφ, and...
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