Article
Enamel defects in Acp4R110C/R110C mice and human ACP4 mutations.
Scientific reports - 1 Oct 2022
Liang Tian, Wang Shih-Kai, Smith Charles, Zhang Hong, Hu Yuanyuan, Seymen Figen, Koruyucu Mine, Kasimoglu Yelda, Kim Jung-Wook, Zhang Chuhua, Saunders Thomas L, Simmer James P, Hu Jan C-C
Abstract excerpt
Human ACP4 (OMIM*606362) encodes a transmembrane protein that belongs to histidine acid phosphatase (ACP) family. Recessive mutations in ACP4 cause non-syndromic hypoplastic amelogenesis imperfecta (AI1J, OMIM#617297). While ACP activity has long been detected in developing teeth, its functions during tooth development and the pathogenesis of ACP4-associated AI remain largely unknown. Here, we characterized 2...
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