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Article

Clinically relevant variation in FLT3-ITD quantitation as a result of PCR cycle number and ITD insertion size.

Pathology - 1 Feb 2023

Tiong Ing S, Andrieska Nikky, Dang Phuong, Jones Kate, Thompson Ella, McBean Michelle, Blombery Piers

Abstract excerpt

FLT3 internal tandem duplication (ITD) quantitation is key to prognostication in acute myeloid leukaemia (AML). One potential source of variability in the allelic ratio (AR) is the number of polymerase chain reaction (PCR) cycles used. Using 30 archived samples of varying ITD lengths and AR, we compared two FLT3-ITD assays (Huang and RATIFY), evaluated the effect of PCR cycle number on each assay, and examined...

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Identifiers

PMID: 36153154
DOI: 10.1016/j.pathol.2022.07.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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