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Article

Human Cardiac Pericytes Are Susceptible to SARS-CoV-2 Infection

14 Sept 2022

Abstract excerpt

COVID-19 is associated with serious cardiovascular complications, with incompletely understood mechanism(s). Pericytes have key functions in supporting endothelial cells and maintaining vascular integrity. We demonstrate that human cardiac pericytes are permissive to SARS-CoV-2 infection in organotypic slice and primary cell cultures. Viral entry into pericytes is mediated by endosomal proteases, and infection...

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PMID: 36124009
DOI: 10.1016/j.jacbts.2022.09.001

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