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Pangenomic analysis of Chinese gastric cancer

15 Sept 2022

Abstract excerpt

Pangenomic study might improve the completeness of human reference genome (GRCh38) and promote precision medicine. Here, we use an automated pipeline of human pangenomic analysis to build gastric cancer pan-genome for 185 paired deep sequencing data (370 samples), and characterize the gene presence-absence variations (PAVs) at whole genome level. Genes ACOT1, GSTM1, SIGLEC14 and UGT2B17 are identified as highly...

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PMID: 36109518
DOI: 10.1038/s41467-022-33073-7

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