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Article

A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 May 2015

Onal Melda, Bishop Kathleen A, St John Hillary C, Danielson Allison L, Riley Erin M, Piemontese Marilina, Xiong Jinhu, Goellner Joseph J, O'Brien Charles A, Pike J Wesley

Abstract excerpt

Receptor activator of NF-κB ligand (RANKL) is a TNFα-like cytokine that is produced by a diverse set of lineage-specific cells and is involved in a wide variety of physiological processes that include skeletal remodeling, lymph node organogenesis, mammary gland development, and thermal regulation. Consistent with these diverse functions, control of RANKL expression is accomplished in a cell-specific fashion via a...

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Source

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Identifiers

PMID: 25431114
DOI: 10.1002/jbmr.2417
PMCID: PMC5240630

Genes

PTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse.PMID 25431114Read ↗

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