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Porcine reproductive and respiratory syndrome virus nsp4-mediated β2M downregulation contributes to SLA-I decrease and virus infection in vivo and in vitro.

Virology - 1 Jul 2024

Kang Lei, Wahaab Abdul, Qi Pengfei, Qiu Yafeng, Wei Jianchao, Li Beibei, Shao Donghua, Li Zongjie, Liu Ke, Ma Zhiyong, Su Shuo

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) infection inhibits swine leukocyte antigen class I (SLA-I) expression in pigs, resulting in inefficient antigen presentation and subsequent low levels of cellular PRRSV-specific immunity as well as persistent viremia. We previously observed that the non-structural protein 4 (nsp4) of PRRSV contributed to inhibition of the β2-microglobulin (β2M) and SLA-I...

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PMID: 38696887
DOI: 10.1016/j.virol.2024.110083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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