DEGBOE: Discrete time Evolution modeling of Gene mutation through Bayesian inference using qualitative Observation of mutation Events.

Abstract excerpt

An important aspect of cancer progression concerns the way in which gene mutations accumulate in cellular lineages. Comprehensive efforts into cataloging cancer genes have revealed that tumors demonstrate variability in genes that accumulate mutations which depend on the presence or absence of other mutations. However, understanding the stochastic process by which mutations arise across the genome is an important...

Topics

• Bayes Theorem
• Humans
• Lung Neoplasms
• Mutation
• Proto-Oncogene Proteins p21(ras)
• Tumor Suppressor Protein p53