Article
A mutation to a fish ice-binding protein synthesized in transgenic Caenorhabditis elegans modulates its cold tolerance.
Biochemical and biophysical research communications - 5 Nov 2022
Kuramochi Masahiro, Zhu Shumiao, Takanashi Chiaki, Yang Yue, Arai Tatsuya, Shinkai Yoichi, Doi Motomichi, Mio Kazuhiro, Tsuda Sakae, Sasaki Yuji C
Abstract excerpt
A cryoprotectant known as ice-binding protein (IBP) is thought to facilitate the cold survival of plants, insects, and fungi. Here, we prepared a genetically modified Caenorhabditis elegans strain to synthesize fish-derived IBPs in its body wall muscles and examined whether the antifreeze activity modification of this IBP by point mutation affects the cold tolerance of this worm. We chose a 65-residue IBP...
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