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Article

Redosing Adeno-Associated Virus Gene Therapy to the Central Nervous System

1 Sept 2022

Abstract excerpt

Adeno-associated virus (AAV)-mediated gene therapies have provided promising treatments for numerous neurological disorders. Redosing of AAV to the central nervous system (CNS) is an attractive research area due to both the somewhat immunologically privileged status of the CNS as well as the possibility of reduced glial transgene expression over time following a single injection. Continued study of the immune...

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PMID: 36074937
DOI: 10.1089/hum.2022.170

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