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KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies.

Critical reviews in oncology/hematology - 1 Jan 2025

Liguori Luigi, Salomone Fabio, Viggiano Angela, Sabbatino Francesco, Pepe Stefano, Formisano Luigi, Bianco Roberto, Servetto Alberto

Abstract excerpt

Kristen rat sarcoma viral oncogene homolog (KRAS) mutations play a major role in the carcinogenesis of many types of solid tumors including non-small cell lung cancer (NSCLC). Among KRAS mutations, p.G12C single-nucleotide variant (KRASG12C) is the most frequently reported in NSCLC patients, with a prevalence of about 12-13 %. For many decades, KRAS mutations including KRASG12C were considered "undruggable"...

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PMID: 39522850
DOI: 10.1016/j.critrevonc.2024.104554

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