Article
Pancreatic beta-cell function dynamics in youth with GCK, HNF1A, and KCNJ11 genes mutations during mixed meal tolerance test.
Pediatric diabetes - 1 Nov 2022
Stankute Ingrida, Dobrovolskiene Rimante, Danyte Evalda, Steponaviciute Rasa, Schwitzgebel Valerie M, Verkauskiene Rasa
Abstract excerpt
OBJECTIVE: The aims were (1) to assess beta-cell function in GCK diabetes patients over 2-year period; (2) to evaluate the dynamics of beta-cell function in HNF1A and KCNJ11 patients after treatment optimization; using mixed meal tolerance test (MMTT) as a gold standard for non-invasive beta-cell function assessment. RESEARCH DESIGN AND METHODS: Twenty-two GCK diabetes patients, 22 healthy subjects, 4 patients...
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