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Histone deacetylase SirE regulates development, DNA damage response and aflatoxin production in Aspergillus flavus

5 Sept 2022

Abstract excerpt

Aspergillus flavus is a ubiquitous saprotrophic soil-borne pathogenic fungus that causes crops contamination with the carcinogen aflatoxins. Although sirtuin E (SirE) is known to be a NAD-dependent histone deacetylase involved in global transcriptional regulation. Its biological functions in A. flavus are not fully understood. To explore the effects of SirE, we found that SirE was located in the nucleus and...

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PMID: 36059183
DOI: 10.1111/1462-2920.16198

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