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Fungus-Specific Sirtuin HstD Coordinates Secondary Metabolism and Development through Control of LaeA

1 Jun 2013

Abstract excerpt

The sirtuins are members of the NAD(+)-dependent histone deacetylase family that contribute to various cellular functions that affect aging, disease, and cancer development in metazoans. However, the physiological roles of the fungus-specific sirtuin family are still poorly understood. Here, we determined a novel function of the fungus-specific sirtuin HstD/Aspergillus oryzae Hst4 (AoHst4), which is a homolog of...

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PMID: 23729383
DOI: 10.1128/ec.00003-13

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