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Article

LATE-NC aggravates GVD-mediated necroptosis in Alzheimer’s disease

3 Sept 2022

Abstract excerpt

Abstract It has become evident that Alzheimer’s Disease (AD) is not only linked to its hallmark lesions—amyloid plaques and neurofibrillary tangles (NFTs)—but also to other co-occurring pathologies. This may lead to synergistic effects of the respective cellular and molecular players, resulting in neuronal death. One of these co-pathologies is the accumulation of phosphorylated transactive-response DNA binding...

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PMID: 36057624
DOI: 10.1186/s40478-022-01432-6

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