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Specific Gait Changes in Prodromal Hereditary Spastic Paraplegia Type 4: preSPG4 Study

29 Aug 2022

Abstract excerpt

BACKGROUND: In hereditary spastic paraplegia type 4 (SPG4), subclinical gait changes might occur years before patients realize gait disturbances. The prodromal phase of neurodegenerative disease is of particular interest to halt disease progression by future interventions before impairment has manifested. OBJECTIVE: The objective of this study was to identify specific movement abnormalities before the...

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PMID: 36054444
DOI: 10.1002/mds.29199

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