Article
Individual changes in preclinical spinocerebellar ataxia identified via increased motor complexity.
Movement disorders : official journal of the Movement Disorder Society - 1 Dec 2016
Ilg Winfried, Fleszar Zofia, Schatton Cornelia, Hengel Holger, Harmuth Florian, Bauer Peter, Timmann Dagmar, Giese Martin, Schöls Ludger, Synofzik Matthis
Abstract excerpt
BACKGROUND: Movement changes in autosomal-dominant spinocerebellar ataxias are suggested to occur many years before clinical manifestation. Detecting and quantifying these changes in the preclinical phase offers a window for future treatment interventions and allows the clinician to decipher the earliest dysfunctions starting the evolution of spinocerebellar ataxia. We hypothesized that quantitative movement...
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