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Article

Patient-Relevant Digital-Motor Outcomes for Clinical Trials in Hereditary Spastic Paraplegia Type 7

2 Dec 2024

Abstract excerpt

BACKGROUND AND OBJECTIVES: With targeted treatment trials on the horizon, identification of sensitive and valid outcome measures becomes a priority for >100 spastic ataxias. While digital-motor measures, assessed using wearable sensors, are considered prime outcome candidates for spastic ataxias, genotype-specific validation studies are lacking. We here aimed to identify candidate digital-motor outcomes for...

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PMID: 39621946
DOI: 10.1212/wnl.0000000000209887

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