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Two distinct classes of thymic tumors in patients with MEN1 show LOH at the MEN1 locus

13 Sept 2021

Abstract excerpt

Patients with the multiple endocrine neoplasia type 1 (MEN1) syndrome carry germline heterozygous loss-of-function mutations in the MEN1 gene which predisposes them to develop various endocrine and non-endocrine tumors. Over 90% of the tumors show loss of heterozygosity (LOH) at chromosome 11q13, the MEN1 locus, due to somatic loss of the wild-type MEN1 allele. Thymic neuroendocrine tumors (NETs) or thymic...

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PMID: 34515662
DOI: 10.1530/erc-21-0226

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