Article
Novel risk genes for systemic lupus erythematosus predicted by random forest classification.
Scientific reports - 24 Jul 2017
Almlöf Jonas Carlsson, Alexsson Andrei, Imgenberg-Kreuz Juliana, Sylwan Lina, Bäcklin Christofer, Leonard Dag, Nordmark Gunnel, Tandre Karolina, Eloranta Maija-Leena, Padyukov Leonid, Bengtsson Christine, Jönsen Andreas, Dahlqvist Solbritt Rantapää, Sjöwall Christopher, Bengtsson Anders A, Gunnarsson Iva, Svenungsson Elisabet, Rönnblom Lars, Sandling Johanna K, Syvänen Ann-Christine
Abstract excerpt
Genome-wide association studies have identified risk loci for SLE, but a large proportion of the genetic contribution to SLE still remains unexplained. To detect novel risk genes, and to predict an individual's SLE risk we designed a random forest classifier using SNP genotype data generated on the "Immunochip" from 1,160 patients with SLE and 2,711 controls. Using gene importance scores defined by the random...
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