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Effects of ulcerative colitis and Crohn’s disease on neurodegenerative diseases: A Mendelian randomization study

15 Aug 2022

Abstract excerpt

Background: Both ulcerative colitis (UC) and Crohn’s disease (CD) are associated with neurodegenerative diseases (NDs) in observational studies, but the causality remains controversial. We aimed to use Mendelian randomization (MR) analysis to explore causal associations between UC and CD and NDs. Methods: We used single nucleotide polymorphisms (SNPs) associated (p < 5 × 10−8) with UC and CD as instrumental...

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PMID: 36046231
DOI: 10.3389/fgene.2022.846005

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