The causal impact of genetically predicted inflammatory bowel disease on extraintestinal manifestations: a mendelian randomization study.

Abstract excerpt

BACKGROUND: Extraintestinal manifestations (EIMs) significantly affect the life quality of people with inflammatory bowel disease (IBD) and are crucial factors impacting occurrence rates and mortality among IBD patients. This study performed a Mendelian randomization (MR) analysis to investigate the causal relationships between genetically predicted IBD and the development of EIMs, including erythema nodosum...

Topics

• Humans
• Mendelian Randomization Analysis
• Polymorphism, Single Nucleotide
• Genome-Wide Association Study
• Crohn Disease
• Cholangitis, Sclerosing