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Article

Somatic mutations in specific and connected subpathways are associated with short neuroblastoma patients' survival and indicate proteins targetable at onset of disease.

International journal of cancer - 15 Nov 2018

Esposito Maria Rosaria, Binatti Andrea, Pantile Marcella, Coppe Alessandro, Mazzocco Katia, Longo Luca, Capasso Mario, Lasorsa Vito Alessandro, Luksch Roberto, Bortoluzzi Stefania, Tonini Gian Paolo

Abstract excerpt

Neuroblastoma (NB) is an embryonic malignancy of the sympathetic nervous system with heterogeneous biological, morphological, genetic and clinical characteristics. Although genomic studies revealed the specific biological features of NB pathogenesis useful for new therapeutic approaches, the improvement of high-risk (HR)-NB patients overall survival remains unsatisfactory. To further clarify the biological basis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29992558
DOI: 10.1002/ijc.31748

Genes

PTK2
CHD2
SMO
ANK3
ARHGEF11
FGF4
LAMA2
LAMA4
MET
MMP14
NALCN
NID2
NTNG2
PTPRA
SFI1
SMARCA4
SPTLC2
VCL
ZNF44

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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