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Profiling chromosomal‐level variations in gastric malignancies

25 Aug 2022

Abstract excerpt

Aneuploidy arises from persistent chromosome segregation errors, or chromosomal instability. Although it has long been known as a hallmark of cancer cells, reduced cellular fitness upon induced ploidy alterations hinders the understanding of how aneuploidy relates to cancer development in the body. In this study, we used FISH analysis targeting centromeres to indicate ploidy changes, and quantitatively evaluated...

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PMID: 36002148
DOI: 10.1111/cas.15544

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