Modelling the HPRT-gene mutation induction of particle beams: systematicin vitrodata collection, analysis and microdosimetric kinetic model implementation.

Abstract excerpt

Objective. Since the early years, particle therapy treatments have been associated with concerns for late toxicities, especially secondary cancer risk (SCR). Nowadays, this concern is related to patients for whom long-term survival is expected (e.g. breast cancer, lymphoma, paediatrics). In the aim to contribute to this research, we present a dedicated statistical and modelling analysis aiming at improving our...

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