Single‐cell RNA‐sequencing dissects cellular heterogeneity and identifies two tumor‐suppressing immune cell subclusters in HPV‐related cervical adenosquamous carcinoma

Abstract excerpt

Abstract The intratumor heterogeneity of human papillomavirus (HPV)‐related cervical cancer remains poorly defined. We performed single‐cell RNA sequencing on 18 046 individual cells derived from two HPV‐related cervical adenosquamous carcinoma samples to analyze the transcriptional heterogeneity of both epithelial and immune constituents, identifying seven epithelial (Epi1‐7) and 11 immune subclusters. Based on...

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