Article
A comparison of DP-TOF Mass Spectroscopy (MS) and Next Generation Sequencing (NGS) methods for detecting molecular mutations in thyroid nodules fine needle aspiration biopsies.
Frontiers in endocrinology - 1 Jan 2022
Qian Xiao-Qin, Agyekum Enock Adjei, Zhao Ling-Ling, Yu Run-Liu, Li Xiu-Ying, Gu De-Jian, Yan Na, Xu Ming, Yuan Yuan, Wang Yu-Guo, Xin-Ping Wu, Xu Fei-Ju
Abstract excerpt
Mutations in the B-Raf proto-oncogene, serine/threonine kinase (BRAF), have been linked to a variety of solid tumors such as papillary thyroid carcinoma. The purpose of this study was to compare the DP-TOF, a DNA mass spectroscopy (MS) platform, and next-generation sequencing (NGS) methods for detecting multiple-gene mutations (including BRAFV600E) in thyroid nodule fine-needle aspiration fluid. In this study, we...
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