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Article

Spatial Gene Expression Changes in the Mouse Heart After Base-Targeted Irradiation

17 Aug 2022

Abstract excerpt

PURPOSE: Radiation cardiotoxicity (RC) is a clinically significant adverse effect of treatment for patients with thoracic malignancies. Clinical studies in lung cancer have indicated that heart substructures are not uniformly radiosensitive, and that dose to the heart base drives RC. In this study, we aimed to characterize late changes in gene expression using spatial transcriptomics in a mouse model of base...

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Share to Cardiac Fibrosis and Remodeling
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PMID: 35985456
DOI: 10.1016/j.ijrobp.2022.08.031

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