Article
Differential Gene Expression in Sporadic and Genetic Forms of Alzheimer's Disease and Frontotemporal Dementia in Brain Tissue and Lymphoblastoid Cell Lines.
Molecular neurobiology - 1 Oct 2022
Ramos-Campoy Oscar, Lladó Albert, Bosch Beatriz, Ferrer Mireia, Pérez-Millan Agnès, Vergara Miguel, Molina-Porcel Laura, Fort-Aznar Laura, Gonzalo Ricardo, Moreno-Izco Fermín, Fernandez-Villullas Guadalupe, Balasa Mircea, Sánchez-Valle Raquel, Antonell Anna
Abstract excerpt
Sporadic early-onset Alzheimer's disease (EOAD) and autosomal dominant Alzheimer's disease (ADAD) provide the opportunity to investigate the physiopathological mechanisms in the absence of aging, present in late-onset forms. Frontotemporal dementia (FTD) causes early-onset dementia associated to tau or TDP43 protein deposits. A 15% of FTD cases are caused by mutations in C9orf72, GRN, or MAPT genes....
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