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Delivering CRISPR: a review of the challenges and approaches

1 Jan 2018

Abstract excerpt

Gene therapy has long held promise to correct a variety of human diseases and defects. Discovery of the Clustered Regularly-Interspaced Short Palindromic Repeats (CRISPR), the mechanism of the CRISPR-based prokaryotic adaptive immune system (CRISPR-associated system, Cas), and its repurposing into a potent gene editing tool has revolutionized the field of molecular biology and generated excitement for new and...

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PMID: 29801422
DOI: 10.1080/10717544.2018.1474964

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