Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression.

Brain pathology (Zurich, Switzerland) - 1 Apr 2014

Koelsche Christian, Sahm Felix, Wöhrer Adelheid, Jeibmann Astrid, Schittenhelm Jens, Kohlhof Patricia, Preusser Matthias, Romeike Bernd, Dohmen-Scheufler Hildegard, Hartmann Christian, Mittelbronn Michel, Becker Albert, von Deimling Andreas, Capper David

Abstract excerpt

BRAF V600E mutation and homozygous deletion of CDKN2A (p16) are frequent molecular alterations in pleomorphic xanthoastrocytomas (PXAs). We investigated 49 PXAs for clinical, histological and immunohistochemical characteristics related to BRAF mutation status. BRAF mutation was detected by immunohistochemical assay and DNA sequencing in 38/49 (78%) tumors. All but one PXA located in the temporal lobe harbored a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD34
Share to Astrocytoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Brain Neoplasms

Share to Child, Preschool

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Diagnosis, Differential

Share to Glial Fibrillary Acidic Protein

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 24345274
DOI: 10.1111/bpa.12111
PMCID: PMC8029045

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRAF-mutated pleomorphic xanthoastrocytoma is associated with temporal location, reticulin fiber deposition and CD34 expression.PMID 24345274Read ↗

The evolution of pleomorphic xanthoastrocytoma: from genesis to molecular alterations and mimics.Semantic proximity Read ↗

Pleomorphic xanthoastrocytoma, anaplastic pleomorphic xanthoastrocytoma, and epithelioid glioblastoma: Case series with clinical characteristics, molecular features and progression relationship.Semantic proximity Read ↗

Noninvasive prediction of BRAF V600E mutation status of pleomorphic xanthoastrocytomas with MRI morphologic features and diffusion-weighted imaging.Semantic proximity Read ↗

pRB immunostaining in the differential diagnosis between pleomorphic xanthoastrocytoma and glioblastoma with giant cells.Semantic proximity Read ↗

A Rare Case of BRAF-mutated Metastatic Pleomorphic Xanthoastrocytoma Patient who Developed Radiodermatitis After Receiving Anti-BRAF Treatment.Semantic proximity Read ↗

Epithelioid GBMs show a high percentage of BRAF V600E mutation.Semantic proximity Read ↗

Clinicopathological and genetic association between epithelioid glioblastoma and pleomorphic xanthoastrocytomaSemantic proximity Read ↗

Pleomorphic xanthoastrocytoma is a heterogeneous entity with pTERT mutations prognosticating shorter survival.Semantic proximity Read ↗

Pleomorphic Xanthoastrocytoma, Anaplastic Pleomorphic Xanthoastrocytoma, and Epithelioid Glioblastoma: Case Series with Clinical Characteristics, Molecular Features and Progression RelationshipSemantic proximity Read ↗

BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications.Semantic proximity Read ↗

Molecular Features and Prognostic Factors of Pleomorphic Xanthoastrocytoma: A Collaborative Investigation of the Tohoku Brain Tumor Study Group.Semantic proximity Read ↗

MRI characteristics predict BRAF V600E status in gangliogliomas and pleomorphic xanthoastrocytomas and provide survival prognostication.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.