Article
Analysis of Histomorphologic/Molecular Association and Immune Checkpoint Regulators in Epithelioid Glioblastoma and Pleomorphic Xanthoastrocytoma: Are These Tumors Potential Candidates for Immune Checkpoint Blockade?
Applied immunohistochemistry & molecular morphology : AIMM - 1 Feb 2024
Mahajan Swati, Singh Jyotsna, Dandapath Iman, Jha Prerana, Chaturvedi Sujata, Ahuja Arvind, Bhardwaj Minakshi, Saran Ravindra, Garg Ajay, Sharma Mehar C, Manjunath Niveditha, Suri Ashish, Sarkar Chitra, Suri Vaishali
Abstract excerpt
Accurate diagnosis of Epithelioid glioblastoma (eGB) and pleomorphic xanthoastrocytoma (PXA) is sometimes challenging owing to overlapping histologic and genetic features. There are limited reports on the immune profile of these tumors. In this study, we assessed 21 PXA [15 PXA Grade 2 (PXAG2); 6 PXA Grade 3 (PXAG3)] and 14 eGB for their histopathological and molecular association. Further, their immune profile...
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