Article
Disease-related thrombocytopenia in myelofibrosis is defined by distinct genetic etiologies and is associated with unique prognostic correlates.
Cancer - 1 Oct 2022
Kuykendall Andrew T, Mo Qianxing, Sallman David A, Ali Najla Al, Chan Onyee, Yun Seongseok, Sweet Kendra L, Padron Eric, Lancet Jeffrey E, Komrokji Rami S
Abstract excerpt
BACKGROUND: Thrombocytopenia in patients with myelofibrosis (MF) is prognostically detrimental and poses a therapeutic challenge. MF patients with thrombocytopenia are considered high-risk by most prognostic models and their distinct phenotype has given rise to the emerging concept of cytopenic MF. Yet, the mechanisms underlying thrombocytopenia in MF are poorly understood. METHODS: This study aimed to highlight...
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