Article
Elevated salivary kynurenic acid levels related to enlarged choroid plexus and severity of clinical phenotypes in treatment-resistant schizophrenia.
Brain, behavior, and immunity - 1 Nov 2022
Huang Junchao, Tong Jinghui, Zhang Ping, Zhou Yanfang, Li Yanli, Tan Shuping, Wang Zhiren, Yang Fude, Kochunov Peter, Chiappelli Joshua, Tian Baopeng, Tian Li, Hong L Elliot, Tan Yunlong
Abstract excerpt
Patients with treatment-resistant schizophrenia (TRS) suffer severe, long-term psychotic symptoms and chronic stress. Salivary kynurenic acid (KYNA) and choroid plexus were evidenced to relate to psychological stress. We hypothesized that TRS patients would have higher salivary KYNA levels than patients who respond to antipsychotics (NTRS) and healthy controls (HC), and increased salivary KYNA levels are...
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