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Association of IRGM promoter region polymorphisms and haplotype with pulmonary tuberculosis in Pakistani (Punjab) population.

Tuberculosis (Edinburgh, Scotland) - 1 Sept 2022

Zafar Ayesha, Shafiq Mohsin, Ali Basharat, Sadee Wolfgang, Shakoori Abdul Rauf, Shakoori Farah Rauf

Abstract excerpt

Single nucleotide polymorphisms (SNPs) in IRGM are reported to affect Mycobacterium tuberculosis (M.tb) degradation pathway. Here, we aim to screen promoter-region regulatory SNPs of IRGM in Pakistani population. DNA extracted from blood of cohort containing 70 TB patients (TB) and 30 controls subjects (Ctrl), was amplified for IRGM promoter region, followed by DNA sequencing. Group-specific variations were found...

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PMID: 35939988
DOI: 10.1016/j.tube.2022.102233

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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