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Anti-COX-2 autoantibody is a novel biomarker of immune aplastic anemia

4 Aug 2022

Abstract excerpt

In immune aplastic anemia (IAA), severe pancytopenia results from the immune-mediated destruction of hematopoietic stem cells. Several autoantibodies have been reported, but no clinically applicable autoantibody tests are available for IAA. We screened autoantibodies using a microarray containing >9000 proteins and validated the findings in a large international cohort of IAA patients (n = 405) and controls (n =...

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PMID: 35927326
DOI: 10.1038/s41375-022-01654-6

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