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BRCA1, BRCA2, and Associated Cancer Risks and Management for Male Patients: A Review.

JAMA oncology - 1 Sept 2024

Cheng Heather H, Shevach Jeffrey W, Castro Elena, Couch Fergus J, Domchek Susan M, Eeles Rosalind A, Giri Veda N, Hall Michael J, King Mary-Claire, Lin Daniel W, Loeb Stacy, Morgan Todd M, Offit Kenneth, Pritchard Colin C, Schaeffer Edward M, Szymaniak Brittany M, Vassy Jason L, Katona Bryson W, Maxwell Kara N

Abstract excerpt

Importance: Half of all carriers of inherited cancer-predisposing variants in BRCA1 and BRCA2 are male, but the implications for their health are underrecognized compared to female individuals. Germline variants in BRCA1 and BRCA2 (also known as pathogenic or likely pathogenic variants, referred to here as BRCA1/2 PVs) are well known to significantly increase the risk of breast and ovarian cancers in female...

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Identifiers

PMID: 39052257
DOI: 10.1001/jamaoncol.2024.2185

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