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Recapitulating influenza virus infection and facilitating antiviral and neuroprotective screening in tractable brain organoids

1 Jan 2022

Abstract excerpt

Human pluripotent stem cell derived brain organoids offer an unprecedented opportunity for various applications as in vitro model. Currently, human brain organoids as models have been used to understand virus-induced neurotoxicity. Methods: The brain organoids were separately challenged by multiple viruses including influenza viruses (H1N1-WSN and H3N2-HKT68), Enteroviruses (EV68 and EV71) and Severe Fever with...

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PMID: 35910807
DOI: 10.7150/thno.75123

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