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Article

XBP1 is required in Th2 polarization induction in airway allergy

1 Jan 2022

Abstract excerpt

Th2 polarization plays a central role in the pathogenesis of allergic diseases such as airway allergy. The underlying mechanism is not fully understood yet. X-box-binding protein-1 (XBP1) can regulate immune cell activities upon exposing stressful events. The role of XBP1 in the development of Th2 polarization has not yet been explored. Methods: Mice carrying Xbp1-deficient CD4 + T cells were employed to observe...

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PMID: 35910793
DOI: 10.7150/thno.75100

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