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Article

Multi-Cell-Type Openness-Weighted Association Studies for Trait-Associated Genomic Segments Prioritization.

Genes - 8 Jul 2022

Song Shuang, Sun Hongyi, Liu Jun S, Hou Lin

Abstract excerpt

Openness-weighted association study (OWAS) is a method that leverages the in silico prediction of chromatin accessibility to prioritize genome-wide association studies (GWAS) signals, and can provide novel insights into the roles of non-coding variants in complex diseases. A prerequisite to apply OWAS is to choose a trait-related cell type beforehand. However, for most complex traits, the trait-relevant cell...

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PMID: 35886003
DOI: 10.3390/genes13071220
PMCID: PMC9323627

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