Article
Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis.
Genes - 21 Jun 2022
Hawkey-Noble Alexia, Pater Justin A, Kollipara Roshni, Fitzgerald Meriel, Maekawa Alexandre S, Kovacs Christopher S, Young Terry-Lynn, French Curtis R
Abstract excerpt
Bone diseases such as otosclerosis (conductive hearing loss) and osteoporosis (low bone mineral density) can result from the abnormal expression of genes that regulate cartilage and bone development. The forkhead box transcription factor FOXL1 has been identified as the causative gene in a family with autosomal dominant otosclerosis and has been reported as a candidate gene in GWAS meta-analyses for osteoporosis....
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