Article
ASCL2 Maintains Stemness Phenotype through ATG9B and Sensitizes Gliomas to Autophagy Inhibitor.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Sept 2022
Wang Li-Hong, Yuan Ye, Wang Jiao, Luo Ying, Lan Yang, Ge Jia, Li Lei, Liu Feng, Deng Qing, Yan Ze-Xuan, Liang Mei, Wei Sen, Liu Xin-Dong, Wang Yan, Ping Yi-Fang, Shi Yu, Yu Shi-Cang, Zhang Xia, Cui You-Hong, Yao Xiao-Hong, Feng Hua, Luo Tao, Bian Xiu-Wu
Abstract excerpt
Autophagy is a highly conserved process that is vital for tumor progression and treatment response. Although autophagy is proposed to maintain the stemness phenotype in adult diffuse glioma, the molecular basis of the link between autophagy and stemness is poorly understood, which makes it impossible to effectively screen for the population that will benefit from autophagy-targeted treatment. Here, ATG9B as...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.