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Article

Polygenic risk score as a determinant of risk of keratinocyte cancer in an Australian population-based cohort.

Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Nov 2022

Liyanage U E, Law M H, Antonsson A, Hughes M C B, Gordon S, van der Pols J C, Green A C

Abstract excerpt

BACKGROUND: Keratinocyte cancer (KC) risk is determined by genetic and environmental factors. Genetic risk can be quantified by polygenic risk scores (PRS), which sum the combined effects of single nucleotide polymorphisms (SNPs). OBJECTIVES: Our objective here was to evaluate the contribution of the summed genetic score to predict the KC risk in the phenotypically well-characterized Nambour population. METHODS:...

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PMID: 35881107
DOI: 10.1111/jdv.18466

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