Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal rats

29 Jun 2022

Abstract excerpt

Although emerging evidence reveals that vaping alters the function of the central nervous system, the effects of maternal vaping on offspring brain development remain elusive. Using a well-established in utero exposure model, we performed single-nucleus ATAC-seq (snATAC-seq) and RNA sequencing (snRNA-seq) on prenatally e-cigarette-exposed rat brains. We found that maternal vaping distorted neuronal lineage...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to MicroRNA in disease regulation
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35874099
DOI: 10.1016/j.isci.2022.104686

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-nucleus chromatin accessibility and RNA sequencing reveal impaired brain development in prenatally e-cigarette exposed neonatal ratsPMID 35874099Read ↗

Prenatal e-cigarette exposure induces region- and cell type-specific metabolic and developmental reprogrammingSemantic proximity Read ↗

Maternal e-cigarette exposure alters DNA methylome, site-specific CpG and CH methylation, and transcriptomic signatures in the neonatal brainSemantic proximity Read ↗

Hypoxia-Ischemia During a Neonatal Sensitive Period Alters Purkinje Neuron Dendritic Complexity Differently in Male and Female RatsSemantic proximity Read ↗

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoidsSemantic proximity Read ↗

Early-childhood inflammation blunts the transcriptional maturation of cerebellar neuronsSemantic proximity Read ↗

Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamolSemantic proximity Read ↗

Chronic exposure to glucocorticoids amplifies inhibitory neuron cell fate during human neurodevelopment in organoidsSemantic proximity Read ↗

Perinatal Elimination of Genetically Aberrant Neurons from Human Cerebral CortexSemantic proximity Read ↗

Multi-omics approach reveals dysregulated genes during hESCs neuronal differentiation exposure to paracetamolSemantic proximity Read ↗

Sex-Specific Alterations of the Lung Transcriptome at Birth in Mouse Offspring Prenatally Exposed to Vanilla-Flavored E-Cigarette Aerosols and Enhanced Susceptibility to AsthmaSemantic proximity Read ↗

Exposure to a low dose mixture of endocrine disrupting chemicals alters the brain transcriptome and animal behaviorSemantic proximity Read ↗

Cocaine perturbs neurodevelopment and increases neuroinflammation in a prenatal cerebral organoid modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.