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Article

Loss of exosomal miR-34c-5p in cancer-associated fibroblast for the maintenance of stem-like phenotypes of laryngeal cancer cells.

Head & neck - 1 Nov 2022

Wang Mei, Zhuoma Ciwang, Liu Xiaojin, Huang Qiang, Cai Guoyu, Sang Ge, Zhou Liang, Du Huaidong, Wu Chunping

Abstract excerpt

BACKGROUND: Cancer-associated fibroblasts (CAFs) reconstitute cancer stemness. This study aims to investigate whether the loss of CAF-derived exosomal miR-34c-5p contributes to the maintenance of stem-like properties of laryngeal squamous cell carcinoma (LSCC). METHODS: Exosomes from primarily cultured CAFs and paired normal fibroblasts (NFs) were collected and identified. The differential expression of exosomal...

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PMID: 35866307
DOI: 10.1002/hed.27155

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